Murine Kidney Tissue: Unilateral ureteral obstructed mice vs. Sham control

ABSTRACT: INTRODUCTION AND OBJECTIVE: Loss of renal function is often the impetus for operative intervention in renal obstruction. Obstructive nephropathy is characterized discrete morphological and physiologic changes including tubular dilatation, apoptosis, and atrophy, as well as interstitial cellular infiltration and progressive interstitial fibrosis. We hypothesize that there are gene expression alterations correlated with obstructive nephropathy that could serve as biomarkers for early intervention. METHODS: C57BL/6 mice were subjected to Unilateral Urethral Obstruction (UUO) or sham surgery at postnatal day 21 of life, and kidneys were harvested after 1, 2, 5 and 9 days postoperatively. RNA was extracted from kidneys and comprehensive gene expression profiling was performed with Agilent micr

ORGANISM(S): Mus musculus

SUBMITTER: Bo Wu 

PROVIDER: E-GEOD-36496 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress