Genomic analysis for predicting cell culture status in a sparged bench-scale 5L bioreactor

ABSTRACT: There is a great need for setting novel measurable attributes at the cell physiological level in a scalable biopharmaceutical production process to be able to predict the process outcomes and improve process understanding. In a biologic production process, changes in culture environment due to several factors such as shear and bubble induced damage from gas sparging and agitation are known to occur. There is a gap in the knowledge of cellular response due to varying bioreactor environment itself during the course of cell culture, from lag-phase to log-phase to stationary-phase in culture. With the emergence of micro-arrays as tools for exploring cell physiological changes, it opens the possibility for studying the effect of bioreactor culture environment itself on the cell substrate. Such

ORGANISM(S): Mus musculus

SUBMITTER: Bhargavi Kondragunta 

PROVIDER: E-GEOD-33062 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress