RP58 controls neuron and astrocyte differentiation by downregulating the expression of Id1-4 genes in the developing cortex

ABSTRACT: Appropriate number of neurons and glial cells is generated from neural stem cells (NSCs) by the regulation of cell cycle exit and subsequent differentiation. Although the regulatory mechanism remains obscure, Id (inhibitor of differentiation) proteins are known to contribute critically to NSC proliferation by controlling cell cycle. Here we report that a transcriptional factor, RP58, negatively regulates all 4 Id genes (Id1-Id4) in developing cerebral cortex. Consistently, Rp58 knockout (KO) mice demonstrated enhanced astrogenesis accompanied with an excess of NSCs. These phenotypes were mimicked by the overexpression of all Id genes in wild-type cortical progenitors. Furthermore, Rp58 KO phenotypes were rescued by the knockdown of all Id genes in mutant cortical progenitors but not by the

ORGANISM(S): Mus musculus

SUBMITTER: Shinobu Hirai 

PROVIDER: E-GEOD-34327 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress