Response of yeast cells to stress
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Michael Shapira
PROVIDER: E-GEOD-3812 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data.
Segal Eran E Shapira Michael M Regev Aviv A Pe'er Dana D Botstein David D Koller Daphne D Friedman Nir N
Nature genetics 20030601 2
Much of a cell's activity is organized as a network of interacting modules: sets of genes coregulated to respond to different conditions. We present a probabilistic method for identifying regulatory modules from gene expression data. Our procedure identifies modules of coregulated genes, their regulators and the conditions under which regulation occurs, generating testable hypotheses in the form 'regulator X regulates module Y under conditions W'. We applied the method to a Saccharomyces cerevis ...[more]
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