FoxO6 regulates memory consolidation and synaptic function.

ABSTRACT: We used microarrays to assess gene expression differences in the hippocampus between FoxO6 mutant and wild-type siblings before (basal) or after novel object learning. The cohort of basal mice were housed individually for at least 3 days prior to tissue harvesting. The mice used to collect hippocampal samples after the object learning task were handled daily in the procedure room, prior to the object learning task. 24 hours before the object learning task, each mouse was individually habituated to the empty novel object arena for 10 min. On the days of the novel object learning task and the empty arena habituation, the mice were transferred to the procedure room and acclimatized for 60 min. For the novel object learning task, the mice were allowed to explore two identical and novel objects

ORGANISM(S): Mus musculus

SUBMITTER: Duygu Ucar 

PROVIDER: E-GEOD-42097 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress