Canonical nucleosome organization at promoters forms during genome activation

ABSTRACT: The position of nucleosomes influences DNA accessibility to DNA-binding proteins. Genome-wide nucleosome profiles often report the observation of a canonical nucleosome organization at gene promoters where arrays of well-positioned nucleosomes emanate from nucleosome-depleted regions. It is unclear how this canonical promoter nucleosome organization forms and how it is related to transcription activation and the establishment of histone marks during development. Here we report the genome-wide organization of nucleosomes during zebrafish embryogenesis and show that well-positioned nucleosome arrays appear in thousands of promoters during the activation of the zygotic genome. The formation of canonical promoter nucleosome organization cannot be explained by DNA sequence preference, and is in

ORGANISM(S): Danio rerio

SUBMITTER: Yong Zhang 

PROVIDER: E-GEOD-44269 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress