Temporal Concordance between Apical and Transcriptional Points-of-Departure for Chemical Risk Assessment

ABSTRACT: The number of legacy chemicals without toxicity reference values combined with the rate of new chemical development are overwhelming the capacity of the traditional risk assessment paradigm. More efficient approaches are needed to quantitatively estimate chemical risks. In this study, rats were dosed orally with multiple doses of six chemicals for 5 days, 2, 4, and 13 weeks. Target organs were analyzed for traditional histological and organ weight changes and transcriptional changes using microarrays. Histological and organ weight changes in this study and the tumor incidences in the original cancer bioassays were analyzed using benchmark dose (BMD) methods to identify noncancer and cancer points-of-departure. The dose-response changes in gene expression were also analyzed using BMD me

ORGANISM(S): Rattus norvegicus

SUBMITTER: Longlong Yang 

PROVIDER: E-GEOD-45892 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress