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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide gene expression analysis on tibialis anterior muscle from nebulin SH3 domain deleted (Neb∆SH3) mice

ABSTRACT: Genome-wide gene expression analysis on tibialis anterior muscle from 2-month-old nebulin SH3 domain deleted (Neb∆SH3) mice compared to wildtype. Total RNA was obtained from biological triplicates of tibialis anterior muscle from 2-month-old nebulin SH3 domain deleted (Neb∆SH3) mice compared to wildtype.

ORGANISM(S): Mus musculus

SUBMITTER: Paolo Kunderfranco

PROVIDER: E-GEOD-47801 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The nebulin SH3 domain is dispensable for normal skeletal muscle structure but is required for effective active load bearing in mouse.

Yamamoto Daniel L DL Vitiello Carmen C Zhang Jianlin J Gokhin David S DS Castaldi Alessandra A Coulis Gerald G Piaser Fabio F Filomena Maria Carmela MC Eggenhuizen Peter J PJ Kunderfranco Paolo P Camerini Serena S Takano Kazunori K Endo Takeshi T Crescenzi Marco M Luther Pradeep K L PK Lieber Richard L RL Chen Ju J Bang Marie-Louise ML

Journal of cell science 20130917 Pt 23

Nemaline myopathy (NM) is a congenital myopathy with an estimated incidence of 150,000 live births. It is caused by mutations in thin filament components, including nebulin, which accounts for about 50% of the cases. The identification of NM cases with nonsense mutations resulting in loss of the extreme C-terminal SH3 domain of nebulin suggests an important role of the nebulin SH3 domain, which is further supported by the recent demonstration of its role in IGF-1-induced sarcomeric actin filamen ...[more]

PMID: 24046450

Similar Datasets

Genome-wide gene expression analysis on tibialis anterior muscle from nebulin SH3 domain deleted (Neb∆SH3) mice

Project description:Genome-wide gene expression analysis on tibialis anterior muscle from 2-month-old nebulin SH3 domain deleted (Neb∆SH3) mice compared to wildtype.

2013-09-23 | GSE47801 | GEO

Mus musculus

Project description:Genome-wide gene expression analysis on tibialis anterior muscle from nebulin SH3 domain deleted (Neb∆SH3) mice

| PRJNA207822 | ENA

The effect of Nebulin-Deficiency on Skeletal Muscle

Project description:Nebulin is a giant filamentous protein that is coextensive with the actin filaments of the skeletal muscle sarcomere. Nebulin mutations are the main cause of nemaline myopathy (NEM), with typical NEM adult patients having low expression of nebulin, yet the roles of nebulin in adult muscle remain poorly understood. To establish nebulin’s functional roles in adult muscle we performed studies on a novel conditional nebulin KO (Neb cKO) mouse model in which nebulin deletion was driven by the muscle creatine kinase (MCK) promotor. Neb cKO mice are born with high nebulin levels in their skeletal muscle but within weeks after birth nebulin expression rapidly falls to barely detectable levels Surprisingly, a large fraction of the mice survives to adulthood with low nebulin levels (<5% of control), contain nemaline rods, and undergo fiber-type switching towards oxidative types. These microarrays investigate the changes in gene expression when nebulin is deficient.

2015-06-25 | GSE70213 | GEO

The effect of Nebulin-Deficiency on Skeletal Muscle

2015-06-25 | E-GEOD-70213 | biostudies-arrayexpress

Transcription profiling of skeletal muscle from wild type and Nebulin knock-out mice

Project description:Knock out of the Nebulin gene. We compared the Quadriceps of two Nebulin -deficient vs. 2 Wildtype mice. The two KO-WT pairs derived from two litters (F2 generation, background: C57/Bl6 and 129/IB10).

2006-11-01 | E-MEXP-733 | biostudies-arrayexpress

RNA-seq reveals differential expression of potential miR-486 target transcripts

Project description:Identifying microRNA target transcripts is critical in understanding their role in modulation of disease pathology through cellular processes. Here, we used isolated 6 month mouse tibialis anterior (TA) muscle tissue for RNA extraction and sequencing in order to identify mRNA transcripts overexpressed in miR-486 knockout mice compared to wildtype.

2022-05-04 | GSE155787 | GEO

Gene expression profile in PGC1b overexpressing skeletal muscle

Project description:PGC1b transgenic mice were generated to selectively over-express PGC1b in skeletal muscles using human skeletal alpha-actin gene promoter. The gene expression profiles were collected from Tibialis anterior (TA) muscles of wild type (WT) and PGC1b transgenic (TG) mice. Tibialis anterior muscles from three month old WT and PGC1b transgenic male mice.

2014-06-21 | E-GEOD-58699 | biostudies-arrayexpress

Gene expression profile in mouse skeletal muscle after Mettl21e deletion

Project description:Analysis of tibialis anterior (TA) muscle isolated from wildtype (WT) and Mettl21e deletion mice (KO). Results provide unbiased gene expression profile of TA muscle after Mettl21e deletion.

2019-10-22 | GSE122024 | GEO

Profiling of glycerol- and CTX-induced models of muscle regeneration in mice

Project description:Utilizing glycerol and cardiotoxin (CTX) injections in the tibialis anterior muscles of M. musculus provides models of skeletal muscle damages followed by skeletal muscle regeneration. In particular, glycerol-induced muscle regeneration is known to be associated with ectopic adipogenesis. We characterized genome-wide expression profiles of tibialis anterior muscles from wild-type mice injured by either glycerol or CTX injection. Our goal was to detect gene expression changes during the time course of glycerol-induced and CTX-induced muscle regeneration models, that can lead to ectopic adipocyte accumulation. Tibialis anterior muscle of 12 week old wildtype C57BL/6J male mice injected i.m with either glycerol or CTX were collected 3, 7, 14 or 21 days after injection. 6 biological replicates were used for each time points. Please note that a few replicate samples did not pass QC test, thus, were removed from the submission. Unchallenged tibialis anterior muscles from a group of 5 wildtype C57BL/6J mice were also as a control. Total RNA was extracted, QCed and hybridized to Affymetrix microarrays.

2013-08-16 | E-GEOD-45577 | biostudies-arrayexpress

Transcriptional analysis of skeletal muscles from wild type and mdx/mTR mice

Project description:We report RNA sequencing data from tibialis anterior muscles of 4 month old male wild type C57Bl/6 mice and mdx/mTR mice (generated in the C57Bl/6 background), which lack the dystrophin and telomerase RNA component genes.

2019-03-06 | GSE127929 | GEO

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