Transcription profiling of rat nasal respiratory epithelium laser capture microdissected after exposure to hydrogen sulfide

ABSTRACT: Hydrogen sulfide (H2S) is a naturally occurring gas that is also associated with several industries. The potential for widespread human inhalation exposure to this toxic gas is recognized as a public health concern. The nasal epithelium is particularly susceptible to H2S-induced pathology. Injury to and regeneration of the nasal respiratory mucosa occurred in animals with ongoing H2S exposure suggesting that the regenerated respiratory epithelium undergoes an adaptive response and becomes resistant to further H2S induced toxicity. To better understand this adaptive response, twenty-four naive 10-week old male Sprague-Dawley rats were exposed to air or 200 ppm H2S in a nose-only exposure system for 3h/d for 1 or 5 consecutive days. Nasal respiratory epithelial cells at the site of inju

ORGANISM(S): Rattus rattus

SUBMITTER: Elizabeth Sherman Roberts 

PROVIDER: E-GEOD-5349 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress