Divergence of Transcription Factor Binding Sites in Related Yeast Species

ABSTRACT: A fundamental problem in biology is the molecular basis for divergence among related organisms. We have investigated the level of divergence of transcription factor binding sites for two key factors that regulate developmental processes in the budding yeasts. The genomic binding locations for the Ste12 and Tec1 transcription factors in S. cerevisiae, S. mikatae and S. bayanus were mapped by chromatin immunoprecipitation combined with microarrays (chIP chip)1, 2 and compared to one another. While there was a large core network which was conserved in all three species, there were many instances of binding events whose relative levels differ significantly quantitatively in one species relative to another and as well as species-specific binding events. One interesting class of genes were ident

ORGANISM(S): Saccharomyces mikatae

SUBMITTER: Anthony Borneman 

PROVIDER: E-GEOD-5421 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress