High-fat diet-mediated dysbiosis promotes intestinal carcinogenesis independent of obesity

ABSTRACT: Several aspects common to a Western lifestyle, including obesity and decreased physical activity, are known risks for gastrointestinal cancers. There is an increasing amount of evidence suggesting that diet profoundly affects the composition of the intestinal microbiota. Moreover, there is now unequivocal evidence linking a dysbiotic gut to cancer development. Yet, the mechanisms through which high-fat diet (HFD)-mediated changes in the microbial community impact the severity of tumorigenesis in the gut, remain to be determined. Here we demonstrate that HFD promotes tumor progression in the small intestine of genetically susceptible K-rasG12Dint mice independent of obesity. HFD consumption in conjunction with K-Ras mutation mediates a shift in the composition of gut microbiota, which is as

ORGANISM(S): Mus musculus

SUBMITTER: Claudia Pommerenke 

PROVIDER: E-GEOD-56257 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress