Genome accessibility is widely preserved and locally modulated during mitosis [Dnase-seq]

ABSTRACT: Mitosis entails global alterations to chromosome structure and nuclear architecture, concomitant with transient silencing of transcription. How cells transmit transcriptional states through mitosis remains incompletely understood. While many nuclear factors dissociate from mitotic chromosomes, the observation that certain nuclear factors and chromatin features remain associated with individual loci during mitosis originated the hypothesis that they could provide transcriptional memory through mitosis. To obtain the first genome-wide view of the dynamics of chromatin structure during mitosis, we compared the DNase sensitivity of interphase and mitotic chromatin at two stages of cellular maturation in a rapidly dividingmurine erythroblastmodel. Despite global chromosome condensation visible

ORGANISM(S): Mus musculus

SUBMITTER: Ross Hardison 

PROVIDER: E-GEOD-61885 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress