Expression data from asthamtic and healthy airway smooth muscle cells

ABSTRACT: Persistent severe asthma is associated with hyper-contractile airways and structural changes in the airway wall, including an increased airway smooth muscle (ASM) mass. This study used gene expression profiles from asthmatic and healthy airway smooth muscle cells grown in culture to identify novel receptors and pathways that potentially contributed to asthma pathogenesis. We used microarrays to compare the gene expression between asthmatic and healthy airway smooth muscle cells to understand the underlying pathway contributing the differences in cellular phenotypes Asthmatic airway smooth muscle cells (ASMC) are intrinsically different and have a differential transcriptional response to pro-fibrotic, pro-proliferation and pro-inflammatory stimuli than ASMC from healthy patients. We sought

ORGANISM(S): Homo sapiens

SUBMITTER: Alen Faiz 

PROVIDER: E-GEOD-63383 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress