Plasma-specific microRNA responses in rats treated with acute toxicity doses of aristolochic acid I

ABSTRACT: In the present study, goal was to scan the potential biomarker for acute kidney injury induced by aristolochic acid I (AAI).We utilized the microarry analysis to investigate the microRNA (miRNA) expression profile in kidneys from rat treated by 40mg/kg AA I for 2-6 days. miRNAs with significantly different expression of global miRNA expression profile were validated by qRT-PCR. For miRNAs still significantly disregulation, we further examined the expression in plasma of rats treated with AAI dosed at 10, 20 and 40mg/kg AAI for 2-6 days by qRT-PCR. miRNAs with significantly dysregulation in plasma, their expression in brain, liver and heart was examined for kicking out the non-specific disregulation in AAI induced acute kidney injury, so that the significant dysregulation miRNAs with speci

ORGANISM(S): Rattus norvegicus

SUBMITTER: Ze'an Zhang 

PROVIDER: E-GEOD-79063 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress