Transcription profiling of human prostate samples LNCaP cell gene expression during 12 months of androgen deprivation, time series

ABSTRACT: Following androgen ablation therapy (AAT), the vast majority of prostate cancer patients develop treatment resistance with a median time of 18-24 months to disease progression. To identify molecular targets that aid in prostate cancer cell survival and contribute to the androgen independent phenotype, we evaluated changes in LNCaP cell gene expression during 12 months of androgen deprivation. At time points reflecting critical growth and phenotypic changes, we performed Affymetrix expression array analysis to examine the effects of androgen deprivation during the acute response, during the period of apparent quiescence, and during the emergence of highly proliferative, androgen-independent prostate cancer cells (LNCaP-AI). We discovered alterations in gene expression for a host of molecule

ORGANISM(S): Homo sapiens

SUBMITTER: Beth Pflug 

PROVIDER: E-GEOD-8702 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress