Transcription profiling by array of colon from rats with trinitrobenzene sulfuric acid (TNBS) induced colitis after treatment with glycomacropeptide

ABSTRACT: This study looks at the effect of glycomacropeptide (GMP) treatment on rats with trinitrobenzene sulfuric acid (TNBS) induced colitis.

Female Wistar rats (175-225 g) were randomly assigned to three different groups. A control group C (n=3) that did not receive the TNBS challenge but 0.25 ml of phosphate buffered saline (PBS) intrarectally, and two groups (group T (n=3) and group GMP (n=5) that received the TNBS challenge as described below. Group GMP received 500 mg kg-1 day-1 of GMP in 1% methylcellulose p.o, starting two days before the TNBS challenge. Treatment was administered to rats for five days after the TNBS challenge using an oesophageal catheter. The T group received the vehicle. Colitis was induced by the method of Morris et al. with minor modifications (13). Briefly,

ORGANISM(S): Rattus norvegicus

DISEASE(S): normal

SUBMITTER: Olga Martinez-Augustin 

PROVIDER: E-MEXP-1631 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress