Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression profiling of TROP2+ cells from human CRC (colorectal carcinoma) specimens


ABSTRACT: The Trophoblast cell surface antigen 2 (TROP2) is a transmembrane glycoprotein encoded by the Tumor associated calcium signal transducer 2 (TACSTD2) gene. TROP2 is upregulated in many human malignancies including colorectal cancer, and its overexpression correlates with tumor progression, invasiveness, and poor survival. Functional studies revealed that TROP2 may have a role as both an oncogene and a tumor suppressor. To identify TROP2 function in human cancer cells, we performed gene expression profiling of TROP2+ and TROP2- cells isolated from human colon tumors.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Homo sapiens

SUBMITTER:  

PROVIDER: E-MTAB-11466 | biostudies-arrayexpress |

SECONDARY ACCESSION(S): ERP135710

REPOSITORIES: biostudies-arrayexpress

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