Gene expression profiling of TROP2+ cells from human CRC (colorectal carcinoma) specimens

ABSTRACT: The Trophoblast cell surface antigen 2 (TROP2) is a transmembrane glycoprotein encoded by the Tumor associated calcium signal transducer 2 (TACSTD2) gene. TROP2 is upregulated in many human malignancies including colorectal cancer, and its overexpression correlates with tumor progression, invasiveness, and poor survival. Functional studies revealed that TROP2 may have a role as both an oncogene and a tumor suppressor. To identify TROP2 function in human cancer cells, we performed gene expression profiling of TROP2+ and TROP2- cells isolated from human colon tumors. Due to the sensitive nature of the data, raw data files have not been uploaded.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Homo sapiens

SUBMITTER: Jan Kubovčiak 

PROVIDER: E-MTAB-11466 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress