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Time course analysis of human colorectal cancer liver metastasis models under Sacituzumab Govitecan (SG) treatment or untargeted control

ABSTRACT: Human colorectal cancer organoids were injected intrasplenically to form liver metastasis in mice were treated with the TROP2-targeting antibody-drug conjugate Sacituzumab Govitecan (SG) or non-targeting control IgG1-SN-38 (ADC). Tumors were harvested at different time points: 0 h, 6 h, 24 h, 48 h, 72 h and 120 h} and subjected to single-cell RNA-seq using sample hashtag multiplexing.

INSTRUMENT(S): Illumina NovaSeq X

ORGANISM(S): Homo sapiens

SUBMITTER: Maria Puschhof

PROVIDER: E-MTAB-16849 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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