RNA-seq of human bronchial epithelial cells treated with cigarette smoke and mycobacteria

ABSTRACT: Exposure to cigarette smoke (CS) is a known risk factor for pulmonary tuberculosis, and smokers are at increased risk of treatment failure and relapse. Using differentiated primary human bronchial epithelial cells (PBEC), we studied whether there is a direct effect of acute CS exposure on epithelial host responses to infection with Mycobacterium tuberculosis (Mtb) and Mycobacterium avium (Mav). The study population included 8 individual donors, of whom 4 were female. Median age was 66.5 years (range 56-70). Of these donors, none were current smokers, 5 were ex-smokers (62.5%), 2 were non-smokers (25%) and no information was available for 1 donor (12.5%). None of the donors were diagnosed with chronic obstructive pulmonary disease.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: Amy Barclay 

PROVIDER: E-MTAB-17246 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress