Comparative analysis of Bruno-3 gain of function in Drosophila larval muscles

ABSTRACT: Myotonic dystrophy type 1 (DM1) is a neuro-muscular disorder caused by CTG triplet expansion in the 3'-UTR of the DMPK gene. Mutated transcripts aggregate in muscle nuclei and increase CUGBP1 stability by a not-yet determined mechanism. To assess the involvement of CUGBP1 in DM1, we used Drosophila as a model of the disease and we performed genome wide analyses of gene expression of bru-3 (CUGBP1 orthologue) gain of function line (Mef>bru-3) vs. Mef>lacZ control line.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Lucie Picchio 

PROVIDER: E-MTAB-3231 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress