Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcription profiling by array of mouse prefrontal cortex, remaining cortex, cerrebellum and hippocampus from the fastest and slowest learners

ABSTRACT: To gain insights into the molecular underpinnings of general learning abilities in mice

ORGANISM(S): Mus musculus

SUBMITTER: Stefan Kolata

PROVIDER: E-MTAB-330 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Transcription profiling of 12 human ovarian clear cell carcinoma cell lines

Project description:12 ovarian clear cell carcinoma cell lines were transcriptomically profiles using the illumina human v6 chip

2008-11-13 | E-TABM-540 | biostudies-arrayexpress

Transcription profiling by array of human untreated endometrial cancer cell lines

Project description:Gene expression array analysis of 8 untreated endometrial cancer cell lines using Illumina human WG6 version 2

2010-09-25 | E-TABM-992 | biostudies-arrayexpress

Transcription profiling of human KNS42 cells treated with the dual pI3-kinas/mTOR inhibitor PI-103

Project description:Sensitivity to temozolomide (TMZ) is restricted to a subset of glioblastoma patients, with the major determinant of resistance a lack of promoter methylation of the gene encoding the DNA methyltransferase MGMT, although other mechanisms are thought to be active. In a genome-wide screen of paediatric and adult glioma cells, we identified a co-ordinated upregulation of HOX gene expression in the MGMT-independent cell line KNS42. As a recent study has proposed a mechanism for this observation whereby transcriptional activation of the HOXA cluster is reversible by a PI3-kinase inhibitor through an epigenetic mechanism involving histone H3K27 trimethylation, we sought to investigate whether this was active in our system. We thus treated KNS42 cells for 24 hours with the dual PI3-kinase / mTOR inhibitor PI-103 at 5x IC50 and carried out gene expression profiling using Illumina HT-12 microarrays.

2011-01-08 | E-TABM-890 | biostudies-arrayexpress

Transcription profiling of human Wilms tumor cells treated with insulin-like growth factor 1 receptor inhibitors

Project description:We have previously determined the insulin-like growth factor 1 receptor (IGF1R) to be amplified and overexpressed in Wilms tumour. In order to probe the efficacy and mechanisms of action of various inhibitors of the receptor, we have carried out expression profiling of Wilms tumour cells treated with 5x IC50 of the compounds PPP and NVP-AEW541 over a 24 hour time-course.

2011-01-08 | E-TABM-891 | biostudies-arrayexpress

Transcription profiling of human paediatric glioblastoma cells treated with insulin-like growth factor 1 receptor inhibitors

Project description:We have previously determined the insulin-like growth factor 1 receptor (IGF1R) to be amplified and overexpressed in paediatric glioblastoma. In order to probe the efficacy and mechanisms of action of various inhibitors of the receptor, we have carried out expression profiling of paediatric glioblastoma cells treated with 5x IC50 of the compounds PPP and NVP-AEW541 over a 24 hour time-course.

2011-01-08 | E-TABM-889 | biostudies-arrayexpress

Methylation and microRNA profiling of human paediatric glioma cell lines

Project description:Constitutive signalling pathway activation is a key feature of primary tumours and cancer cell lines. The regulation of gene expression changes may be via both genomic and epigenetic means, and understanding the mechanisms by which signal transduction may be activated can provide rational targets for therapeutic intervention. We have previously carried out DNA copy and expression profiling on a unique panel of five paediatric glioma cell lines, and have noted only a limited influence of gene amplification on gene expression. In the present study we have extended our work to include a measure of global methylation changes as well as micro RNA profiling in the same cell lines. We noted various instances of signalling pathway activation associated with specific hypermethylation or miRNA regulation of gene expression at various effectors also observed in primary paediatric tumours. These data provide evidence for the multifaceted nature of gene expression changes in paediatric high grade glioma, and identify novel targets for targeted therapy in this treatment refractory disease.

2010-12-03 | E-TABM-858 | biostudies-arrayexpress

ChIP-chip by array of human mesenchymal stem cells to identify Argonaute1 bound mRNAs and to identify mRNAs expressed by the human embryo stem cell line H1 before and after differentiation along the neural lineage.

Project description:Gene expression profiles were generated with Illumina arrays for untreated human mesenchymal stem cells and also Argonaute1 bound mRNAs in the same cells. In addition gene expression profiles were generated for the human embryo cell line H1 before and after differentiation along the neural lineage. NOTE: assays for human embryonic stem cells before and after differentiation were added in July 2014 and data files for the mesenchymal stem cells were updated.

2010-12-20 | E-TABM-1001 | biostudies-arrayexpress

Transcription profiling by array of human Acute Myeloid Leukemia samples

Project description: Not available

2011-01-21 | E-TABM-978 | biostudies-arrayexpress

Transcription profiling of human 239T cells shows SUMOylation of DRIL1 directs its transcriptional activity towards leukocyte lineage-specific genes

Project description:SUMOylation of DRIL1 directs its transcriptional activity towards leukocyte lineage-specific genes

2009-06-26 | E-TABM-681 | biostudies-arrayexpress

Transcription profiling, comparative genomic hybridization, genotyping and methylation profiling by array of human breast cancer cell lines

Project description:Integrative analysis of breast cancer cell lines, using expression, comparative genomics, SNP and methylation profiling

2012-11-09 | E-TABM-928 | biostudies-arrayexpress