Transcription profiling of esophageal squamous cells from rats fed different diets with zinc replenishment
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Cristian Taccioli
PROVIDER: E-TABM-501 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Zinc replenishment reverses overexpression of the proinflammatory mediator S100A8 and esophageal preneoplasia in the rat.
Taccioli Cristian C Wan Shao-Gui SG Liu Chang-Gong CG Alder Hansjuerg H Volinia Stefano S Farber John L JL Croce Carlo M CM Fong Louise Y Y LY
Gastroenterology 20081124 3
<h4>Background & aims</h4>Zinc deficiency is implicated in the pathogenesis of human esophageal cancer. In the rat esophagus, it induces cell proliferation, modulates genetic expression, and enhances carcinogenesis. Zinc-replenishment reverses proliferation and inhibits carcinogenesis. The zinc-deficient rat model allows the identification of biological differences affected by zinc during early esophageal carcinogenesis.<h4>Methods</h4>We evaluated gene expression profiles of esophageal epitheli ...[more]
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