Cerebrovascular G_i Proteins Protect Against Brain Hypoperfusion and Collateral Failure in Cerebral Ischemia.

ABSTRACT: Cerebral hypoperfusion and vascular dysfunction are closely related to common risk factors for ischemic stroke such as hypertension, dyslipidemia, diabetes, and smoking. The role of inhibitory G protein-dependent receptor (G_iPCR) signaling in regulating cerebrovascular functions remains largely elusive. We examined the importance of G_iPCR signaling in cerebral blood flow (CBF) and its stability after sudden interruption using various in vivo high-resolution magnetic resonance imaging techniques. To this end, we induced a functional knockout of G_iPCR signaling in the brain vasculature by injection of pertussis toxin (PTX). Our results show that PTX induced global brain hypoperfusion and microvascular collapse. When PTX-pretreated animals underwent transient

SUBMITTER: Castaneda-Vega S 

PROVIDER: S-EPMC10006265 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature