Connectivity alterations of mesostriatal pathways in first episode psychosis.

ABSTRACT:

Background and hypothesis

Pathogenic understanding of the psychotic disorders converges on regulation of dopaminergic signaling in mesostriatocortical pathways. Functional connectivity of the mesostriatal pathways may inform us of the neuronal networks involved.

Study design

This longitudinal study of first episode psychosis (FEP) (49 patients, 43 controls) employed seed-based functional connectivity analyses of fMRI data collected during a naturalistic movie stimulus.

Study results

We identified hypoconnectivity of the dorsal striatum with the midbrain, associated with antipsychotic medication dose in FEP, in comparison with the healthy control group. The midbrain regions that showed hypoconnectivity with the dorsal striatum also showed hypoconnectivity with cerebell

SUBMITTER: Hayward NMEA 

PROVIDER: S-EPMC10014938 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature