Invasive margin tissue-resident macrophages of high CD163 expression impede responses to T cell-based immunotherapy.

ABSTRACT:

Background

Primary and secondary resistance is a major hurdle in cancer immunotherapy. Therefore, a better understanding of the underlying mechanisms involved in immunotherapy resistance is of pivotal importance to improve therapy outcome.

Method

Here, two mouse models with resistance against therapeutic vaccine-induced tumor regression were studied. Exploration of the tumor microenvironment by high dimensional flow cytometry in combination with therapeutic in vivo settings allowed for the identification of immunological factors driving immunotherapy resistance.

Results

Comparison of the tumor immune infiltrate during early and late regression revealed a change from tumor-rejecting toward tumor-promoting macrophages. In concert, a rapid exhaustion of tumor-infi

SUBMITTER: van Elsas MJ 

PROVIDER: S-EPMC10016286 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature