Is an elevated family-genetic risk for major psychiatric disorders specific to creative occupations?

ABSTRACT:

Background

Despite a large descriptive literature linking creativity and risk for psychiatric illness, the magnitude and specificity of this relationship remain controversial.

Methods

We examined, in 1 137 354 native Swedes with one of 59 3-digit official and objective occupational codes in managerial and educated classes, their familial genetic risk score (FGRS) for ten major disorders, calculated from 1^st through 5^th degree relatives. Mean FGRS across disorders were calculated, in 3- and 4-digit occupational groups, and then controlled for those whose disorder onset preceded occupational choice. Using sequential analyses, p values were evaluated using Bonferroni correction.

Results

3-digit professions considered to reflect creativity (e.

SUBMITTER: Kendler KS 

PROVIDER: S-EPMC10016430 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature