Topography of Cholinergic Changes in Dementia With Lewy Bodies and Key Neural Network Hubs.

ABSTRACT:

Objectives

The authors investigated the topography of cholinergic vulnerability in patients with dementia with Lewy bodies (DLB) using positron emission tomography (PET) imaging with the vesicular acetylcholine transporter (VAChT) [¹⁸F]-fluoroethoxybenzovesamicol ([¹⁸F]-FEOBV) radioligand.

Methods

Five elderly participants with DLB (mean age, 77.8 years [SD=4.2]) and 21 elderly healthy control subjects (mean age, 73.62 years [SD=8.37]) underwent clinical assessment and [¹⁸F]-FEOBV PET.

Results

Compared with the healthy control group, reduced VAChT binding in patients with DLB demonstrated nondiffuse regionally distinct and prominent reductions in bilateral opercula and anterior cingulate to mid-cingulate cortices, bilateral insula, rig

SUBMITTER: Kanel P 

PROVIDER: S-EPMC10018718 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature