Dataset Information

Impact of maternal hepatitis B carrier status on congenital abnormalities: a systematic review and meta-analysis.

ABSTRACT:

Objectives

This study aims to explore whether maternal hepatitis B carrier status is associated with an increased risk of congenital abnormalities.

Design

A systematic review and meta-analysis of observational studies.

Data sources

PubMed, Embase (Ovid), Scopus, the China National Knowledge Infrastructure (CNKI) and the Wanfang databases.

Study selection

Five databases were searched systematically from inception to 7 September 2021. Cohort and case-control studies that investigated the association between maternal hepatitis B virus (HBV) infection and congenital abnormalities were included. This study was conducted according to MOOSE (Meta-analysis of Observational Studies in Epidemiology) guidelines.

Data extraction and synthesis

Two reviewers independently collected data, as well as assessed risk of bias by using Newcastle-Ottawa Scale. We pooled crude relative risk (cRR) and adjusted OR (aOR) by DerSimonian-Laird random-effects model. Heterogeneity was explored by I ² statistics, Cochran's Q test. Several subgroup analyses and sensitivity analyses were performed.

Results

In total, 14 studies involving 16 205 pregnant women exposed to HBV were included. The pooled cRR of 1.15 (95% CI: 0.92 to 1.45; 14 studies included) showed a marginal but not significant association between maternal HBV-carrier status and congenital abnormalities. However, the pooled aOR of 1.40 (95% CI: 1.01 to 1.93; 8 studies included) indicated that pregnant women with HBV infection might be associated with a higher risk of congenital abnormalities. Subgroup analyses of adjusted data showed a higher pooling cRR or aOR on high prevalence HBV infection populations, as well as studies from Asia and Oceania.

Conclusions

Maternal hepatitis B carrier status might be at potential risk for congenital abnormalities. The existing evidence was not sufficient to draw a firm conclusion. Additional studies may be warranted to confirm the association.

Prospero registration number

CRD42020205459.

SUBMITTER: Huang S

PROVIDER: S-EPMC10069551 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Impact of maternal hepatitis B carrier status on congenital abnormalities: a systematic review and meta-analysis.

Huang Shiyao S Wang Jing J Xiong Yiquan Y Liu Chunrong C Qi Yana Y Zou Kang K Tan Jing J Sun Xin X

BMJ open 20230328 3

<h4>Objectives</h4>This study aims to explore whether maternal hepatitis B carrier status is associated with an increased risk of congenital abnormalities.<h4>Design</h4>A systematic review and meta-analysis of observational studies.<h4>Data sources</h4>PubMed, Embase (Ovid), Scopus, the China National Knowledge Infrastructure (CNKI) and the Wanfang databases.<h4>Study selection</h4>Five databases were searched systematically from inception to 7 September 2021. Cohort and case-control studies th ...[more]

PMID: 36977541

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Dataset Information

Impact of maternal hepatitis B carrier status on congenital abnormalities: a systematic review and meta-analysis.

Objectives

Design

Data sources

Study selection

Data extraction and synthesis

Results

Conclusions

Prospero registration number

Publications

Impact of maternal hepatitis B carrier status on congenital abnormalities: a systematic review and meta-analysis.

Similar Datasets

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