Vaccination provides superior in vivo recall capacity of SARS-CoV-2-specific memory CD8 T cells.

ABSTRACT: Memory CD8 T cells play an important role in the protection against breakthrough infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whether the route of antigen exposure impacts these cells at a functional level is incompletely characterized. Here, we compare the memory CD8 T cell response against a common SARS-CoV-2 epitope after vaccination, infection, or both. CD8 T cells demonstrate comparable functional capacity when restimulated directly ex vivo, independent of the antigenic history. However, analysis of T cell receptor usage shows that vaccination results in a narrower scope than infection alone or in combination with vaccination. Importantly, in an in vivo recall model, memory CD8 T cells from infected individuals show equal proliferation but secrete less

SUBMITTER: Kavazovic I 

PROVIDER: S-EPMC10070771 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature