Unknown

Dataset Information

0

Different races have different immune microenvironments: comparison of White and Asian patients with liver cancer.


ABSTRACT: Different ethnic groups have different incidence rate of hepatocellular carcinoma (HCC). In addition to lifestyle and environmental factors, genetic susceptibility is also an important reason. In this study, we screened the immune related genes and stromal related genes in White and Asian liver cancer patients cohort of The Cancer Genome Atlas (TCGA) the using ESTIMATE algorithm. Hub genes that significantly associated with overall survival (OS) were selected from White and Asian liver cancer patients, respectively. In addition, we validated the functions of two hub genes, IL-18RAP and GPM6A, in vivo and in vitro. We confirmed different races have different tumor immune microenvironments. Immune microenvironment can influence and change the efficacy of immunotherapy for liver cancer patients.

SUBMITTER: Wen GM 

PROVIDER: S-EPMC10077039 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

altmetric image

Publications

Different races have different immune microenvironments: comparison of White and Asian patients with liver cancer.

Wen Gui-Min GM   Song Chang-Liang CL   Liu Da-Hua DH   Xia Pu P  

American journal of cancer research 20230315 3


Different ethnic groups have different incidence rate of hepatocellular carcinoma (HCC). In addition to lifestyle and environmental factors, genetic susceptibility is also an important reason. In this study, we screened the immune related genes and stromal related genes in White and Asian liver cancer patients cohort of The Cancer Genome Atlas (TCGA) the using ESTIMATE algorithm. Hub genes that significantly associated with overall survival (OS) were selected from White and Asian liver cancer pa  ...[more]

Similar Datasets

| S-EPMC11410263 | biostudies-literature
| S-EPMC10492120 | biostudies-literature
| S-EPMC5732758 | biostudies-literature
| S-EPMC10077047 | biostudies-literature
| S-EPMC9292136 | biostudies-literature
| S-EPMC7459099 | biostudies-literature
| S-EPMC10296905 | biostudies-literature
| S-EPMC10994261 | biostudies-literature
| S-EPMC6776187 | biostudies-literature
2020-03-16 | GSE147043 | GEO