The heterochronic LIN-14 protein is a BEN domain transcription factor.

ABSTRACT: Heterochrony is a foundational concept in animal development and evolution, first introduced by Ernst Haeckel in 1875 and later popularized by Stephen J. Gould¹. A molecular understanding of heterochrony was first established by genetic mutant analysis in the nematode C. elegans, revealing a genetic pathway that controls the proper timing of cellular patterning events executed during distinct postembryonic juvenile and adult stages². This genetic pathway is composed of a complex temporal cascade of multiple regulatory factors, including the first-ever discovered miRNA, lin-4, and its target gene, lin-14, which encodes a nuclear, DNA-binding protein^2,3,4. While all core members of the pathway have homologs based on

SUBMITTER: Greene S 

PROVIDER: S-EPMC10080584 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature