Association between birth by caesarian section and anxiety, self-harm: a gene-environment interaction study using UK Biobank data.

ABSTRACT:

Background

Limited efforts have been paid to explore the underlying genetic mechanisms of birth by caesarian section (CS) affecting the risks of adult anxiety and self-harm.

Methods

Using UK Biobank cohort, the logistic regression model was first applied to evaluate the associations of adult anxiety and self-harm with birth by CS. Using birth by CS as exposure variables, genome-wide by environment interaction study (GWEIS) was then applied by PLINK2.0 to identify associated genes interacting with birth by CS for anxiety and self-harm.

Results

In the observational study, significant associations were observed between birth by CS and anxiety (odds ratio (OR) = 1.24; 95% confidence interval (CI), 1.12-1.38; P = 4.86 × 10^- 5), and self-harm (OR = 1.12; 95% CI,

SUBMITTER: Jia Y 

PROVIDER: S-EPMC10080817 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature