IGFBP5 antisense and short hairpin RNA (shRNA) constructs improve erectile function by inducing cavernosum angiogenesis in diabetic mice.

ABSTRACT:

Background

The incidence of diabetic erectile dysfunction (ED) is rapidly increasing, and due to the severe angiopathy caused by diabetes, current drugs are ineffective at treating ED. Insulin-like growth factor-binding protein 5 (IGFBP5) promotes cell death and induces apoptosis in various cell types.

Objectives

To evaluate the effectiveness of IGFBP5 knockdown in improving erectile function in diabetic mice.

Materials and methods

Diabetes was induced by injecting streptozotocin (STZ) intraperitoneally into male 8-week-old C57BL/6 mice. Eight weeks after diabetes induction, mice were divided into four groups: a nondiabetic control group and three STZ-induced diabetic mice groups, which were administered intracavernous injections of phosphate buffered saline, scramble

SUBMITTER: Ock J 

PROVIDER: S-EPMC10087557 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature