Dataset Information

Delineation of G Protein-Coupled Receptor Kinase Phosphorylation Sites within the D₁ Dopamine Receptor and Their Roles in Modulating β-Arrestin Binding and Activation.

ABSTRACT: The D₁ dopamine receptor (D1R) is a G protein-coupled receptor that signals through activating adenylyl cyclase and raising intracellular cAMP levels. When activated, the D1R also recruits the scaffolding protein β-arrestin, which promotes receptor desensitization and internalization, as well as additional downstream signaling pathways. These processes are triggered through receptor phosphorylation by G protein-coupled receptor kinases (GRKs), although the precise phosphorylation sites and their role in recruiting β-arrestin to the D1R remains incompletely described. In this study, we have used detailed mutational and in situ phosphorylation analyses to completely identify the GRK-mediated phosphorylation sites on the D1R. Our results indicate that GRKs can phosphorylate 14 seri

SUBMITTER: Moritz AE

PROVIDER: S-EPMC10095280 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Dataset Information

Delineation of G Protein-Coupled Receptor Kinase Phosphorylation Sites within the D₁ Dopamine Receptor and Their Roles in Modulating β-Arrestin Binding and Activation.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Delineation of G Protein-Coupled Receptor Kinase Phosphorylation Sites within the D1 Dopamine Receptor and Their Roles in Modulating β-Arrestin Binding and Activation.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Delineation of G Protein-Coupled Receptor Kinase Phosphorylation Sites within the D₁ Dopamine Receptor and Their Roles in Modulating β-Arrestin Binding and Activation.