Simultaneous Broadband Suppression of Homonuclear and Heteronuclear Couplings in ¹ H NMR Spectroscopy.

ABSTRACT: The ¹ H NMR analysis of species containing NMR-active heteronuclei can be difficult due to signal overlap caused by the combined effects of homonuclear and heteronuclear scalar (J) couplings. Here, a general pure shift method is presented for obtaining ultra-high resolution ¹ H NMR spectra where spectral overlap is drastically reduced by suppressing both homonuclear and heteronuclear J-couplings, giving one single signal per ¹ H chemical environment. Its usefulness is demonstrated in the analysis of fluorine- and phosphorus-containing compounds of pharmaceutical and biochemical interest.

SUBMITTER: Mycroft C 

PROVIDER: S-EPMC10099583 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature