Distinct subpopulations of DN1 thymocytes exhibit preferential γδ T lineage potential.

ABSTRACT: The αβ and γδ T cell lineages both differentiate in the thymus from common uncommitted progenitors. The earliest stage of T cell development is known as CD4^-CD8^- double negative 1 (DN1), which has previously been shown to be a heterogenous mixture of cells. Of these, only the CD117⁺ fraction has been proposed to be true T cell progenitors that progress to the DN2 and DN3 thymocyte stages, at which point the development of the αβ and γδ T cell lineages diverge. However, recently, it has been shown that at least some γδ T cells may be derived from a subset of CD117^- DN thymocytes. Along with other ambiguities, this suggests that T cell development may not be as straightforward as previously thought. To better understand early T cell development, pa

SUBMITTER: Oh S 

PROVIDER: S-EPMC10106834 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature