Dataset Information

Seven-day in vivo testing of a novel, low-resistance, pumpless pediatric artificial lung for long-term support.

ABSTRACT:

Introduction

For children with end-stage lung disease that cannot wean from extracorporeal life support (ECLS), a wearable artificial lung would permit extubation and provide a bridge to recovery or transplantation. We evaluate the function of the novel Pediatric MLung-a low-resistance, pumpless artificial lung developed specifically for children-in healthy animal subjects.

Methods

Adolescent "mini sheep" weighing 12-20 kg underwent left thoracotomy, cannulation of the main pulmonary artery (PA; inflow) and left atrium (outflow), and connection to the MLung.

Results

Thirteen sheep were studied; 6 were supported for 7 days. Mean PA pressure was 23.9 ± 6.9 mmHg. MLung blood flow was 633±258 mL/min or 30.0 ± 16.0% of CO. MLung pressure drop was 4.4 ± 3.4 mmHg. Resistance was 7.2 ± 5.2 mmHg/L/min. Device outlet oxygen saturation was 99.0 ± 3.3% with inlet saturation 53.8 ± 7.3%. Oxygen delivery was 41.1 ± 18.4 mL O₂/min (maximum 84.9 mL/min) or 2.8 ± 1.5 mL O₂/min/kg. Platelet count significantly decreased; no platelet transfusions were required. Plasma free hemoglobin significantly increased only on day 7, at which point 2 of the animals had plasma free hemoglobin levels above 50 mg/dL.

Conclusion

The MLung provides adequate gas exchange at appropriate blood flows for the pediatric population in a PA-to-LA configuration. Further work remains to improve the biocompatibility of the device.

Level of evidence

N/A.

SUBMITTER: Fallon BP

PROVIDER: S-EPMC10112847 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Publications

Seven-day in vivo testing of a novel, low-resistance, pumpless pediatric artificial lung for long-term support.

Fallon Brian P BP Thompson Alex J AJ Prater Aaron R AR Buchan Skylar S Alberts Trevor T Hoenerhoff Mark M Rojas-Pena Alvaro A Bartlett Robert H RH Hirschl Ronald B RB

Journal of pediatric surgery 20220713 11

<h4>Introduction</h4>For children with end-stage lung disease that cannot wean from extracorporeal life support (ECLS), a wearable artificial lung would permit extubation and provide a bridge to recovery or transplantation. We evaluate the function of the novel Pediatric MLung-a low-resistance, pumpless artificial lung developed specifically for children-in healthy animal subjects.<h4>Methods</h4>Adolescent "mini sheep" weighing 12-20 kg underwent left thoracotomy, cannulation of the main pulmon ...[more]

PMID: 35953340

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Dataset Information

Seven-day in vivo testing of a novel, low-resistance, pumpless pediatric artificial lung for long-term support.

Introduction

Methods

Results

Conclusion

Level of evidence

Publications

Seven-day in vivo testing of a novel, low-resistance, pumpless pediatric artificial lung for long-term support.

Similar Datasets

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