Longitudinal In Vivo Monitoring of Atheroprogression in Hypercholesterolemic Mice Using Photoacoustic Imaging.

ABSTRACT:

Background and aim

 The ability to recognize and monitor atherosclerotic lesion development using noninvasive imaging is crucial in preventive cardiology. The aim of the present study was to establish a protocol for longitudinal monitoring of plaque lipid, collagen, and macrophage burden as well as of endothelial permeability.

Methods and results

 Photoacoustic signals derived from endogenous or exogenous dyes assessed in vivo, in plaques of albino Apoe ^-/- mice, correlated with lesion characteristics obtained after histomorphometric and immunofluorescence analyses, thus supporting the validity of our protocol. Using models of atheroprogression and regression, we could apply our imaging protocol to the longitudinal observation of atherosclerotic lesion char

SUBMITTER: Ferraro B 

PROVIDER: S-EPMC10113035 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature