Three-Dimensional Humanized Model of the Periodontal Gingival Pocket to Study Oral Microbiome.

ABSTRACT: The oral cavity contains distinct microenvironments that serve as oral barriers, such as the non-shedding surface of the teeth (e.g., enamel), the epithelial mucosa and gingival tissue (attached gingiva) where microbial communities coexist. The interactions and balances between these communities are responsible for oral tissue homeostasis or dysbiosis, that ultimately dictate health or disease. Disruption of this equilibrium can lead to chronic inflammation and permanent tissue damage in the case of chronic periodontitis. There are currently no experimental tissue models able to mimic the structural, physical, and metabolic conditions present in the human oral gingival tissue to support the long-term investigation of host-pathogens imbalances. Herein, the authors report an in vitro 3D anat

SUBMITTER: Adelfio M 

PROVIDER: S-EPMC10131835 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature