Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension.

ABSTRACT:

Background

Pulmonary hypertension (PH) can occur as a complication of schistosomiasis. In humans, schistosomiasis-PH persists despite antihelminthic therapy and parasite eradication. We hypothesized that persistent disease arises as a consequence of exposure repetition.

Methods

Following intraperitoneal sensitization, mice were experimentally exposed to Schistosoma eggs by intravenous injection, either once or three times repeatedly. The phenotype was characterized by right heart catheterization and tissue analysis.

Results

Following intraperitoneal sensitization, a single intravenous Schistosoma egg exposure resulted in a PH phenotype that peaked at 7-14 days, followed by spontaneous resolution. Three sequential exposures resulted in a persistent PH phenotype. Inflam

SUBMITTER: Kumar R 

PROVIDER: S-EPMC10133871 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature