Dataset Information

Individual-level permethrin exposure biomarkers in U.S. army soldiers: comparison of two treatment formulations for military uniforms.

ABSTRACT:

Background

Evidence suggests that wearing permethrin-treated military uniforms is not associated with current adverse health conditions. However, exposure through this route results in permethrin biomarker concentrations considerably higher than those in the U.S.

Population

The U.S. Army is exploring different methods of uniform treatment that reduce exposure while maintaining effective protection from insect vector-borne diseases.

Objective

To compare permethrin exposure when wearing two types of permethrin-treated military uniforms.

Methods

Eight male soldiers participated in a 32-day crossover design study to compare permethrin exposure when wearing the current Army uniform (CurrU) and a uniform with a new applied fabric treatment (NewU). Each soldier wore the uniforms for designated 8 h/day time periods over 3 consecutive days separated by a 'wash-out' week of no exposure. Permethrin exposure was assessed from the urinary concentrations of 3-phenoxybenzoic acid (3-PBA) and of the sum of cis- and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid (∑DCCA). Estimated dose was determined based on ∑DCCA concentrations.

Results

Permethrin exposure biomarkers were 21% (3-PBA, p = 0.025) and 35% (∑DCCA, p < 0.001) lower when wearing the NewU compared to the CurrU; the dose was 33% lower (p = 0.05).

Significance

Findings suggest the new treatment reduces human permethrin exposure biomarkers resulting from wearing-treated military uniforms.

SUBMITTER: Proctor SP

PROVIDER: S-EPMC10140735 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Individual-level permethrin exposure biomarkers in U.S. army soldiers: comparison of two treatment formulations for military uniforms.

Proctor Susan P SP Nguyen V T VT Hebert Ashley A AA Taylor Kathryn M KM McClung Holly L HL Heaton Kristin J KJ Ospina Maria M Calafat Antonia M AM

Journal of exposure science & environmental epidemiology 20220823 1

<h4>Background</h4>Evidence suggests that wearing permethrin-treated military uniforms is not associated with current adverse health conditions. However, exposure through this route results in permethrin biomarker concentrations considerably higher than those in the U.S.<h4>Population</h4>The U.S. Army is exploring different methods of uniform treatment that reduce exposure while maintaining effective protection from insect vector-borne diseases.<h4>Objective</h4>To compare permethrin exposure w ...[more]

PMID: 35999257

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Dataset Information

Individual-level permethrin exposure biomarkers in U.S. army soldiers: comparison of two treatment formulations for military uniforms.

Background

Population

Objective

Methods

Results

Significance

Publications

Individual-level permethrin exposure biomarkers in U.S. army soldiers: comparison of two treatment formulations for military uniforms.

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