Genome Mining and Screening for Secondary Metabolite Production in the Endophytic Fungus <i>Dactylonectria alcacerensis</i> CT-6.

ABSTRACT: Endophytic fungi are a treasure trove of natural products with great chemical diversity that is largely unexploited. As an alternative to the traditional bioactivity-guided screening approach, the genome-mining-based approach provides a new methodology for obtaining novel natural products from endophytes. In our study, the whole genome of an endophyte, Dactylonectria alcacerensis CT-6, was obtained for the first time. Genomic analysis indicated that D. alcacerensis CT-6 has one 61.8 Mb genome with a G+C content of 49.86%. Gene annotation was extensively carried out using various BLAST databases. Genome collinearity analysis revealed that D. alcacerensis CT-6 has high homology with three other strains of the Dactylonectria genus. AntiSMASH analysis displayed 45 s

SUBMITTER: Ming Q 

PROVIDER: S-EPMC10142127 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature