Association of parental divorce, discord, and polygenic risk with children's alcohol initiation and lifetime risk for alcohol use disorder.

ABSTRACT:

Background

Parental divorce and discord are associated with poorer alcohol-related outcomes for offspring. However, not all children exposed to these stressors develop alcohol problems. Our objective was to test gene-by-environment interaction effects whereby children's genetic risk for alcohol problems modifies the effects of parental divorce and discord to predict alcohol outcomes.

Methods

The sample included European (EA; N = 5608, 47% male, M_age  ~ 36 years) and African (AA; N = 1714, 46% female, M_age  ~ 33 years) ancestry participants from the Collaborative Study on the Genetics of Alcoholism. Outcomes included age at initiation of regular drinking and lifetime DSM-5 alcohol use disorder (AUD). Predictors included parental divorce, parental relatio

SUBMITTER: Kuo SI 

PROVIDER: S-EPMC10149624 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature