High-Contrast PET Imaging with [18F]NT160, a Class-IIa Histone Deacetylase Probe for In Vivo Imaging of Epigenetic Machinery in the Central Nervous System.
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ABSTRACT:
SUBMITTER: Turkman N
PROVIDER: S-EPMC10150721 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
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High-Contrast PET Imaging with [<sup>18</sup>F]NT160, a Class-IIa Histone Deacetylase Probe for In Vivo Imaging of Epigenetic Machinery in the Central Nervous System.
Turkman Nashaat N Xu Sulan S Huang Chun-Han CH Eyermann Christopher C Salino Julia J Khan Palwasha P
Journal of medicinal chemistry 20230417 8
We utilized positron emission tomography (PET) imaging in vivo to map the spatiotemporal biodistribution/expression of class-IIa histone deacetylases (class-IIa HDACs) in the central nervous system (CNS). Herein we report an improved radiosynthesis of [<sup>18</sup>F]NT160 using 4-hydroxy-TEMPO which led to a significant improvement in radiochemical yield and molar activity. PET imaging with [<sup>18</sup>F]NT160, a highly potent class-IIa HDAC inhibitor, led to high-quality and high-contrast im ...[more]
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