Dataset Information

High-Contrast PET Imaging with [¹⁸F]NT160, a Class-IIa Histone Deacetylase Probe for In Vivo Imaging of Epigenetic Machinery in the Central Nervous System.

ABSTRACT: We utilized positron emission tomography (PET) imaging in vivo to map the spatiotemporal biodistribution/expression of class-IIa histone deacetylases (class-IIa HDACs) in the central nervous system (CNS). Herein we report an improved radiosynthesis of [¹⁸F]NT160 using 4-hydroxy-TEMPO which led to a significant improvement in radiochemical yield and molar activity. PET imaging with [¹⁸F]NT160, a highly potent class-IIa HDAC inhibitor, led to high-quality and high-contrast images of the brain. [¹⁸F]NT160 displayed excellent pharmacokinetic and imaging characteristics: brain uptake is high in gray matter regions, tissue kinetics are appropriate for a ¹⁸F-tracer, and specific binding for class-IIa HDACs is demonstrated by self-blockade. Higher uptake

SUBMITTER: Turkman N

PROVIDER: S-EPMC10150721 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Dataset Information

High-Contrast PET Imaging with [¹⁸F]NT160, a Class-IIa Histone Deacetylase Probe for In Vivo Imaging of Epigenetic Machinery in the Central Nervous System.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

High-Contrast PET Imaging with [18F]NT160, a Class-IIa Histone Deacetylase Probe for In Vivo Imaging of Epigenetic Machinery in the Central Nervous System.

OmicsDI is part of the ELIXIR infrastructure

Tweets

High-Contrast PET Imaging with [¹⁸F]NT160, a Class-IIa Histone Deacetylase Probe for In Vivo Imaging of Epigenetic Machinery in the Central Nervous System.