Age-related changes in plasma biomarkers and their association with mortality in COVID-19.

ABSTRACT:

Background

Coronavirus disease 2019 (COVID-19)-induced mortality occurs predominantly in older patients. Several immunomodulating therapies seem less beneficial in these patients. The biological substrate behind these observations is unknown. The aim of this study was to obtain insight into the association between ageing, the host response and mortality in patients with COVID-19.

Methods

We determined 43 biomarkers reflective of alterations in four pathophysiological domains: endothelial cell and coagulation activation, inflammation and organ damage, and cytokine and chemokine release. We used mediation analysis to associate ageing-driven alterations in the host response with 30-day mortality. Biomarkers associated with both ageing and mortality were validated in an intensiv

SUBMITTER: Michels EHA 

PROVIDER: S-EPMC10151455 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature