Alpha Synuclein Modulates Mitochondrial Ca ²⁺ Uptake from ER During Cell Stimulation and Under Stress Conditions.

ABSTRACT: Alpha synuclein (a-syn) is an intrinsically disordered protein prevalent in neurons, and aggregated forms are associated with synucleinopathies including Parkinson' disease (PD). Despite the biomedical importance and extensive studies, the physiological role of a-syn and its participation in etiology of PD remain uncertain. We showed previously in model RBL cells that a-syn colocalizes with mitochondrial membranes, depending on formation of N-terminal helices and increasing with mitochondrial stress. ¹ We have now characterized this colocalization and functional correlates in RBL, HEK293, and N2a cells. We find that expression of a-syn enhances stimulated mitochondrial uptake of Ca ²⁺ from the ER, depending on formation of its N-terminal helices but not on its disorde

SUBMITTER: Ramezani M 

PROVIDER: S-EPMC10168219 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature