Regional patterns of human cortex development correlate with underlying neurobiology.

ABSTRACT: Human brain morphology undergoes complex changes over the lifespan. Despite recent progress in tracking brain development via normative models, current knowledge of underlying biological mechanisms is highly limited. We demonstrate that human cortical thickness development and aging trajectories unfold along patterns of molecular and cellular brain organization, traceable from population-level to individual developmental trajectories. During childhood and adolescence, cortex-wide spatial distributions of dopaminergic receptors, inhibitory neurons, glial cell populations, and brain-metabolic features explain up to 50% of variance associated with a lifespan model of regional cortical thickness trajectories. In contrast, modeled cortical thickness change patterns during adulthood are best exp

SUBMITTER: Lotter LD 

PROVIDER: S-EPMC10187287 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature