LDL-Dependent Regulation of TNFα/PGE₂ Induced COX-2/mPGES-1 Expression in Human Macrophage Cell Lines.

ABSTRACT: Inflammation is a hallmark in severe diseases such as atherosclerosis and non-alcohol-induced steatohepatitis (NASH). In the development of inflammation, prostaglandins, especially prostaglandin E₂ (PGE₂), are major players alongside with chemo- and cytokines, like tumor-necrosis-factor alpha (TNFα) and interleukin-1 beta (IL-1β). During inflammation, PGE₂ synthesis can be increased by the transcriptional induction of the two key enzymes: cyclooxygenase 2 (COX-2), which converts arachidonic acid to PGH₂, and microsomal prostaglandin E2 synthase 1 (mPGES-1), which synthesizes PGE₂ from PGH₂. Both COX-2 and mPGES-2 were induced by a dietary intervention where mice were fed a fatty acid-rich and, more importantly, cholesterol-r

SUBMITTER: Neuschafer-Rube F 

PROVIDER: S-EPMC10188574 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature