Multisystem inflammatory syndrome in 1.2 million children: longitudinal cohort study of risk factors.

ABSTRACT:

Background

We identified patient characteristics associated with an increased risk of developing MIS-C.

Methods

We conducted a longitudinal cohort study of 1,195,327 patients aged 0-19 years between 2006 and 2021, including the first two waves of the pandemic (February 25-August 22, 2020 and August 23, 2020-March 31, 2021). Exposures included prepandemic morbidity, birth outcomes, and family history of maternal disorders. Outcomes included MIS-C, Kawasaki disease, and other Covid-19 complications during the pandemic. We calculated risk ratios (RRs) and 95% confidence intervals (CIs) for the association between patient exposures and these outcomes using log-binomial regression models adjusted for potential confounders.

Results

Among 1,195,327 children, 84 developed MIS

SUBMITTER: Auger N 

PROVIDER: S-EPMC10191400 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature