Longitudinal bleeding assessment in von Willebrand disease utilizing an interim bleeding score.

ABSTRACT:

Background

Assessment of bleeding phenotype is critically important in the diagnosis of von Willebrand disease (VWD). Despite advances in bleeding assessment tools (BATs), standardized tools to evaluate bleeding following diagnosis (interim bleeding) are lacking.

Objectives

We assessed the clinical utility of an interim bleeding protocol in a multicenter, international study involving patients with VWD.

Methods

The enrolment ISTH BAT formed the original bleeding score (0 BS). At follow-up, the International Society on Thrombosis and Haemostasis BAT was repeated but included only interval bleeding (Interim BS, 1 BS). Both scores were annualized (0 BS/yr, 1 BS/yr). BS were analyzed by VWD subtype, plasma VWF level, sex, and age.

Results

Interim BS discriminated b

SUBMITTER: Lavin M 

PROVIDER: S-EPMC10193460 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature